Which of the following factors can lead to a vehicle skidding?

Over acceleration is a significant factor that can lead to vehicle skidding. When a driver rapidly increases the engine's power without corresponding traction from the tires, especially on slippery surfaces, it can cause the wheels to spin faster than the vehicle's ability to maintain grip on the road. This loss of traction can result in the vehicle sliding or skidding uncontrollably, often leading to dangerous situations.

The other factors listed have varying degrees of impact on vehicle safety and stability. For instance, excessive tire pressure can affect the tire's contact with the road, potentially decreasing grip, but it doesn't typically cause skidding directly. Driving with the windows open has negligible effect on vehicle handling, while a low fuel level may impact the operation of the vehicle, but it does not directly lead to skidding. Thus, over acceleration is the primary contributor to a vehicle losing traction and skidding.